The Winter lab studies basic, translational, and clinical aspects of pancreatic cancer with a principal goal to discover new and effective therapies. We seek to understand how pancreatic cancers develop resistance to standard chemotherapies. Additionally, we are interested in understanding how pancreatic cancer is able to successfully adapt to the extremely harsh metabolic conditions that are present throughout the tumor microenvironment such as hypoxia and low nutrient levels. Our aim is to design therapies that specifically target these adaptive mechanisms. Our research program integrates several different model systems for our research investigations, including tissue culture models derived from the patients we treat, commercial cell lines, mouse models of pancreatic cancer, and clinical data with a complementary biological tissue repository.